Matrixyl
A skin conditioning peptide ingredient listed in EU cosmetic databases—often used in anti-aging formulas.
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✨ real molecule sketch
Spotted this on a label?
Palmitoyl Pentapeptide-4
That’s the INCI name—the official way it appears on the back of your serum or cream. Same ingredient, different marketing names.
Structure (cute edition)
✨ real molecule sketch
Five amino acids linked together, with a palmitic acid tail—signal-peptide style, meant to nudge collagen chatter in skin.
INCI: PALMITOYL PENTAPEPTIDE-4 · ~5 amino acids in our simplified view
Research & public records
Counts and links from public databases (PubMed, ClinicalTrials.gov, Wikidata, NIH drug nomenclature). Educational only — not medical advice.
Knowledge base: chemical compound — Wikipedia
PubMed: 12 indexed papers (search PubMed)
- Nanostructure and Collagen-Stimulating Activity of Cationic Pentapeptide Lipopeptides. · Journal of peptide science : an official publication of the European Peptide Society
- Synergistic Effects of Injectable Platelet-Rich Fibrin and Bioactive Peptides on Dermal Fibroblast Viability and Extracellular Matrix Gene Expression: An In Vitro Study. · Molecules (Basel, Switzerland)
- Self-Assembly and Wound Healing Activity of Biomimetic Cycloalkane-Based Lipopeptides. · ACS applied materials & interfaces
- Boosting Cosmeceutical Peptides: Coupling Imidazolium-Based Ionic Liquids to Pentapeptide-4 Originates New Leads with Antimicrobial and Collagenesis-Inducing Activities. · Microbiology spectrum
- Matrixyl Patch vs Matrixyl Cream: A Comparative In Vivo Investigation of Matrixyl (MTI) Effect on Wound Healing. · ACS omega
- The Effects of a Novel Series of KTTKS Analogues on Cytotoxicity and Proteolytic Activity. · Molecules (Basel, Switzerland)
- N-Terminal Acetylation and C-Terminal Amidation of Spirulina platensis-Derived Hexapeptide: Anti-Photoaging Activity and Proteomic Analysis. · Marine drugs
- Turning a Collagenesis-Inducing Peptide Into a Potent Antibacterial and Antibiofilm Agent Against Multidrug-Resistant Gram-Negative Bacteria. · Frontiers in microbiology
ChEMBL: CHEMBL581242
What brands say it does
Palmitoyl Pentapeptide-4 EU CosIng describes it as: Lysine, synthetic pentapeptide with serine, and threonine, hexadecanoyl derivatives.. In skin care it is typically a supporting active—meant to complement hydrators and antioxidants rather than work alone.
Where you’ll find it
Anti-aging serums, moisturizers, and multi-peptide complexes. Look for Palmitoyl Pentapeptide-4 on the INCI list.
Other names you might see
Palmitoyl Pentapeptide-4
Matrixyl 3000
Where to buy
Real purchase links from Sephora, Ulta, Target, and Amazon — typical prices $10.90–$34.00.
Compare with similar peptides
Similar peptides
Educational only—not medical advice. Results vary; talk to a dermatologist for personal recommendations.