Argireline
Marketed as a topical option for people who want something gentler than injectables for forehead and smile lines.
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✨ real molecule sketch
Spotted this on a label?
Acetyl Hexapeptide-8
That’s the INCI name—the official way it appears on the back of your serum or cream. Same ingredient, different marketing names.
Structure (cute edition)
✨ real molecule sketch
A six-amino-acid chain (acetyl hexapeptide-8)—the INCI name behind Argireline.
INCI: ACETYL HEXAPEPTIDE-8 · ~6 amino acids in our simplified view
Research & public records
Counts and links from public databases (PubMed, ClinicalTrials.gov, Wikidata, NIH drug nomenclature). Educational only — not medical advice.
Knowledge base: clinical trial
PubMed: 23 indexed papers (search PubMed)
- Ex Vivo Evaluation of Skin Permeability Enhancement Using TargetCool in Human-Derived Skin Tissue Models. · The Journal of craniofacial surgery
- The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies. · International journal of cosmetic science
- Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients. · International journal of biological macromolecules
- Fluorous oligoarginines as supra-enhancers for intracellular and transdermal peptide delivery. · Bioactive materials
- Oligomeric hyaluronic acid-modified liposomes effectively improved skin permeability and anti-ageing activity of ellagic acid. · Scientific reports
- Safety Assessment of Acetyl Hexapeptide-8 Amide as Used in Cosmetics. · International journal of toxicology
- Dual-function supramolecular system of α-hydroxy acid-based ionic liquids and peptides for enhanced anti-aging transdermal delivery. · Journal of materials chemistry. B
- Acetyl Hexapeptide-8 in Cosmeceuticals-A Review of Skin Permeability and Efficacy. · International journal of molecular sciences
Clinical trials: 6 studies on ClinicalTrials.gov (view search)
- Topical Acetyl Hexapeptide-8 and the Cosmetic Appearance of Oily Skin · COMPLETED
- Argireline in Treatment of Periorbital Wrinkles · COMPLETED
- A Clinical Trial to Evaluate the Effects of an Eye Serum on Improving the Appearance of the Periorbital Area · COMPLETED
- A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of Blepharospasm · COMPLETED
- Investigating the Wrinkle Reduction Potential of a Novel Compounded Skin Care Cream · COMPLETED
- Acetyl Hexapeptide-8 for Blepharospasm · TERMINATED
ChEMBL: CHEMBL109185
What brands say it does
Argireline is sometimes called a "topical botox-like" peptide in marketing copy. In plain terms, brands position it to soften the look of expression lines by influencing how facial muscles contract under the skin. Expect subtle, gradual changes—not overnight smoothing.
Where you’ll find it
Forehead serums, eye treatments, and "line softening" concentrates.
Other names you might see
Acetyl Hexapeptide-8
Argireline Amplified
Where to buy
Real purchase links from Sephora, Ulta, Target, and Amazon — tap a product to check price and buy.
Compare with similar peptides
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Educational only—not medical advice. Results vary; talk to a dermatologist for personal recommendations.