Argireline
A humectant, skin conditioning peptide ingredient listed in EU cosmetic databases—often used in expression lines formulas.
Back to all peptides
✨ real molecule sketch
Spotted this on a label?
Acetyl Hexapeptide-8
That’s the INCI name—the official way it appears on the back of your serum or cream. Same ingredient, different marketing names.
Structure (cute edition)
✨ real molecule sketch
A six-amino-acid chain (acetyl hexapeptide-8)—the INCI name behind Argireline.
INCI: ACETYL HEXAPEPTIDE-8 · ~6 amino acids in our simplified view
Research & public records
Counts and links from public databases (PubMed, ClinicalTrials.gov, Wikidata, NIH drug nomenclature). Educational only — not medical advice.
Knowledge base: clinical trial
PubMed: 23 indexed papers (search PubMed)
- DES-mediated self-assembled polypeptides: Synergistic neuromuscular signaling inhibition for anti-aging. · Biomaterials advances
- Cosmetic potential of Ganoderma lucidum (Reishi) extract in a topical cream formulation. · International journal of cosmetic science
- BAK and ARG Have Moisturizing, Anti-Inflammatory, Antioxidant, and Antioxidant Bioactivities, in the Zebrafish Model. · Journal of cosmetic dermatology
- Cosmeceuticals in photoaging: A review. · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
- Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis. · JMIR dermatology
- Polydioxanone Bioactive Sutures-Acetyl Hexapeptide-8 (Argireline): An Intelligent System for Controlled Release in Facial Harmonization. · Journal of cutaneous and aesthetic surgery
- Investigating the effects of Argireline in a skin serum containing hyaluronic acids on skin surface wrinkles using the Visia(®) Complexion Analysis camera system for objective skin analysis. · GMS Interdisciplinary plastic and reconstructive surgery DGPW
- Influence of the modification of the cosmetic peptide Argireline on the affinity toward copper(II) ions. · Journal of peptide science : an official publication of the European Peptide Society
Clinical trials: 6 studies on ClinicalTrials.gov (view search)
- Acetyl Hexapeptide-8 for Blepharospasm · TERMINATED
- A Clinical Trial to Evaluate the Effects of an Eye Serum on Improving the Appearance of the Periorbital Area · COMPLETED
- Investigating the Wrinkle Reduction Potential of a Novel Compounded Skin Care Cream · COMPLETED
- Argireline in Treatment of Periorbital Wrinkles · COMPLETED
- A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of Blepharospasm · COMPLETED
- Topical Acetyl Hexapeptide-8 and the Cosmetic Appearance of Oily Skin · COMPLETED
ChEMBL: CHEMBL109185
What brands say it does
Acetyl Hexapeptide-8 EU CosIng describes it as: Acetyl hexapeptide-8 is the synthetic peptide consisting of arginine, methionine, and acetylated glutamic acid residues.. In skin care it is typically a supporting active—meant to complement hydrators and antioxidants rather than work alone.
Where you’ll find it
Forehead serums, smile-line treatments, and peptide "line softening" products. Look for Acetyl Hexapeptide-8 on the INCI list.
Other names you might see
Acetyl Hexapeptide-8
Argireline Amplified
Where to buy
Real purchase links from Sephora, Ulta, Target, and Amazon — typical prices $9.70.
Compare with similar peptides
Similar peptides
Educational only—not medical advice. Results vary; talk to a dermatologist for personal recommendations.