Pentapeptide-4
A skin conditioning peptide ingredient listed in EU cosmetic databases—often used in anti-aging formulas.
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✨ real molecule sketch
Spotted this on a label?
Pentapeptide-4
That’s the INCI name—the official way it appears on the back of your serum or cream. Same ingredient, different marketing names.
Structure (cute edition)
✨ real molecule sketch
Pentapeptide-4 is a synthetic peptide containing lysine, serine and threonine.
INCI: PENTAPEPTIDE-4 · ~5 amino acids in our simplified view
Research & public records
Counts and links from public databases (PubMed, ClinicalTrials.gov, Wikidata, NIH drug nomenclature). Educational only — not medical advice.
PubMed: 16 indexed papers (search PubMed)
- A framework for the safety evaluation of peptides in cosmetics. · Current research in toxicology
- Synergistic Effects of Injectable Platelet-Rich Fibrin and Bioactive Peptides on Dermal Fibroblast Viability and Extracellular Matrix Gene Expression: An In Vitro Study. · Molecules (Basel, Switzerland)
- Enhancement of wound healing in diabetic mice by topical use of a peptide-ionic liquid conjugate. · The international journal of biochemistry & cell biology
- Bioactive Glycyrrhizic Acid Ionic Liquid Self-Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti-Photoaging Signal Peptides. · Advanced science (Weinheim, Baden-Wurttemberg, Germany)
- Dually functionalized dendrimer for stimuli-responsive release of active ingredients into the skin. · Acta biomaterialia
- Erratum for Gomes et al., "Boosting Cosmeceutical Peptides: Coupling Imidazolium-Based Ionic Liquids to Pentapeptide-4 Originates New Leads with Antimicrobial and Collagenesis-Inducing Activities". · Microbiology spectrum
- Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet. · The Journal of clinical and aesthetic dermatology
- Boosting Cosmeceutical Peptides: Coupling Imidazolium-Based Ionic Liquids to Pentapeptide-4 Originates New Leads with Antimicrobial and Collagenesis-Inducing Activities. · Microbiology spectrum
Clinical trials: 1 studies on ClinicalTrials.gov (view search)
- A Single-Group Study to Evaluate the Effects of an Eyelash Serum on Improving Eyelash Growth · COMPLETED
ChEMBL: CHEMBL1159980
What brands say it does
Pentapeptide-4 EU CosIng describes it as: Pentapeptide-4 is a synthetic peptide containing lysine, serine and threonine.. In skin care it is typically a supporting active—meant to complement hydrators and antioxidants rather than work alone.
Where you’ll find it
Anti-aging serums, moisturizers, and multi-peptide complexes. Look for Pentapeptide-4 on the INCI list.
Other names you might see
Pentapeptide-4
Similar peptides
Educational only—not medical advice. Results vary; talk to a dermatologist for personal recommendations.