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Prolyl Hydroxyproline

A skin conditioning miscellaneous peptide ingredient listed in EU cosmetic databases—often used in anti-aging formulas.

Prolyl Hydroxyproline illustration
Reading ingredients on a skincare label

Spotted this on a label?

Prolyl Hydroxyproline

That’s the INCI name—the official way it appears on the back of your serum or cream. Same ingredient, different marketing names.

Structure (cute edition)

Simplified amino acid chain for Prolyl Hydroxyproline

Prolyl Hydroxyproline is the synthetic peptide consisting of proline and hydroxyproline.

INCI: PROLYL HYDROXYPROLINE · ~4 amino acids in our simplified view

Research & public records

Counts and links from public databases (PubMed, ClinicalTrials.gov, Wikidata, NIH drug nomenclature). Educational only — not medical advice.

Knowledge base: scientific article

ChEMBL: CHEMBL1222321

What brands say it does

Prolyl Hydroxyproline EU CosIng describes it as: Prolyl Hydroxyproline is the synthetic peptide consisting of proline and hydroxyproline.. In skin care it is typically a supporting active—meant to complement hydrators and antioxidants rather than work alone.

Where you’ll find it

Anti-aging serums, moisturizers, and multi-peptide complexes. Look for Prolyl Hydroxyproline on the INCI list.

Other names you might see

Prolyl Hydroxyproline

Where to buy

Real purchase links from Sephora, Ulta, Target, and Amazon — tap a product to check price and buy.

Super Saturated Hydrating Barrier Serum with 30% Glycerin + Polyglutamic Acid
Experiment

Super Saturated Hydrating Barrier Serum with 30% Glycerin + Polyglutamic Acid

$28.00 · ★ 4.5676

Shop at Sephora →

Similar peptides

Educational only—not medical advice. Results vary; talk to a dermatologist for personal recommendations.