Hexapeptide-53
A skin conditioning peptide ingredient listed in EU cosmetic databases—often used in expression lines formulas.
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Spotted this on a label?
Hexapeptide-53
That’s the INCI name—the official way it appears on the back of your serum or cream. Same ingredient, different marketing names.
Structure (cute edition)
Hexapeptide-53 is the peptide consisting of alanine, glycine, leucine, proline and tyrosine synthesized to be identical to a portion of the peptide from Melittin found in bees and wasps.
INCI: HEXAPEPTIDE-53 · ~6 amino acids in our simplified view
Research & public records
Counts and links from public databases (PubMed, ClinicalTrials.gov, Wikidata, NIH drug nomenclature). Educational only — not medical advice.
ChEMBL: CHEMBL109185
What brands say it does
Hexapeptide-53 EU CosIng describes it as: Hexapeptide-53 is the peptide consisting of alanine, glycine, leucine, proline and tyrosine synthesized to be identical to a portion of the peptide from Melittin found in bees and wasps.. In skin care it is typically a supporting active—meant to complement hydrators and antioxidants rather than work alone.
Where you’ll find it
Forehead serums, smile-line treatments, and peptide "line softening" products. Look for Hexapeptide-53 on the INCI list.
Other names you might see
Hexapeptide-53
Similar peptides
Educational only—not medical advice. Results vary; talk to a dermatologist for personal recommendations.