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Acetyl Tetrapeptide-5

An eye-area peptide often marketed for puffiness and tired-looking under-eyes.

Close-up healthy skin
Reading ingredients on a skincare label

Spotted this on a label?

Acetyl Tetrapeptide-5

That’s the INCI name—the official way it appears on the back of your serum or cream. Same ingredient, different marketing names.

Structure (cute edition)

Simplified amino acid chain for Acetyl Tetrapeptide-5
2D chemical structure from PubChem ✨ real molecule sketch

Four amino acids—often pitched for eye-area puffiness (Eyeseryl).

INCI: ACETYL TETRAPEPTIDE-5 · ~4 amino acids in our simplified view

Research & public records

Counts and links from public databases (PubMed, ClinicalTrials.gov, Wikidata, NIH drug nomenclature). Educational only — not medical advice.

Knowledge base: chemical compound

ChEMBL: SULFAMETHOXYPYRIDAZINE ACETYL · max phase -1.0

What brands say it does

Brands position this peptide to improve fluid drainage around the eyes and reduce the look of bags and puffiness. It is a supporting ingredient—helpful in a good eye cream, not a substitute for sleep or allergies treatment.

Where you’ll find it

Eye gels, depuffing serums, and brightening eye treatments.

Other names you might see

Eyeseryl Acetyl Tetrapeptide-5

Compare with similar peptides

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Educational only—not medical advice. Results vary; talk to a dermatologist for personal recommendations.