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Tetrapeptide-54

A skin conditioning peptide ingredient listed in EU cosmetic databases—often used in eyes formulas.

Tetrapeptide-54 illustration
Reading ingredients on a skincare label

Spotted this on a label?

Tetrapeptide-54

That’s the INCI name—the official way it appears on the back of your serum or cream. Same ingredient, different marketing names.

Structure (cute edition)

Simplified amino acid chain for Tetrapeptide-54

Tetrapeptide-54 is the synthetic peptide consisting of arginine, isoleucine and lysine.

INCI: TETRAPEPTIDE-54 · ~4 amino acids in our simplified view

Research & public records

Counts and links from public databases (PubMed, ClinicalTrials.gov, Wikidata, NIH drug nomenclature). Educational only — not medical advice.

ChEMBL: CHEMBL3644309

What brands say it does

Tetrapeptide-54 EU CosIng describes it as: Tetrapeptide-54 is the synthetic peptide consisting of arginine, isoleucine and lysine.. In skin care it is typically a supporting active—meant to complement hydrators and antioxidants rather than work alone.

Where you’ll find it

Eye creams, depuffing gels, and brightening treatments. Look for Tetrapeptide-54 on the INCI list.

Other names you might see

Tetrapeptide-54

Compare with similar peptides

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Educational only—not medical advice. Results vary; talk to a dermatologist for personal recommendations.